Appendix to “Depression – Environmental Causes and Natural Treatments”

This page is an appendix to the article “Depression – Environmental Causes and Natural Treatments“. Hay fever, asthma, and urticaria have also been linked to depression, bipolar disorder, other mental disorders, and suicide.1–8 Cytokine therapy, multiple types of vaccines, and endotoxin administration have been shown to induce depressive symptoms that can sometimes last for several […]


This page is an appendix to the article “Depression – Environmental Causes and Natural Treatments“.

Hay fever, asthma, and urticaria have also been linked to depression, bipolar disorder, other mental disorders, and suicide.1–8

Cytokine therapy, multiple types of vaccines, and endotoxin administration have been shown to induce depressive symptoms that can sometimes last for several weeks.9–19

Saffron was found to be as effective as fluoxetine in three different trials.20–22

A 2008 trial found magnesium to be as effective as imipramine in treating depression in diabetics, without any of the side effects of the drug.23,24

Many other studies, including at least four more meta-analyses or systematic reviews, have found an association between poor quality diet and depression.25–45

Raw fruits and vegetables appear to be better than processed fruits and vegetables.46

There is conflicting evidence regarding vegetarian versus omnivore diets.47–52

Saffron and depression meta-analyses and systematic reviews: 53–55

More recent positive RCTs of saffron and depression since the above reviews: 56,57

Despite popular belief, vitamin C deficiency or depletion is common, with incidences ranging from 5% to 25% even in the United States and the UK. In other countries like India, it may be as high as 74%.58–60

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